Targeting histone deacetylases for heart diseases.

Gang Jin, Kaiyue Wang, Yaohui Zhao, Shuo Yuan, Zhangxu He, Jingyu Zhang

Bioorganic chemistry 2023 Sep

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Histone deacetylases (HDACs) are responsible for the deacetylation of lysine residues in histone or non-histone substrates, leading to the regulation of many biological functions, such as gene transcription, translation and remodeling chromatin. Targeting HDACs for drug development is a promising way for human diseases, including cancers and heart diseases. In particular, numerous HDAC inhibitors have revealed potential clinical value for the treatment of cardiac diseases in recent years. In this review, we systematically summarize the therapeutic roles of HDAC inhibitors with different chemotypes on heart diseases. Additionally, we discuss the opportunities and challenges in developing HDAC inhibitors for the treatment of cardiac diseases. Copyright © 2023 Elsevier Inc. All rights reserved.

Citation

Gang Jin, Kaiyue Wang, Yaohui Zhao, Shuo Yuan, Zhangxu He, Jingyu Zhang. Targeting histone deacetylases for heart diseases. Bioorganic chemistry. 2023 Sep;138:106601