A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate.

Jincan Chen, Yang Zhou, Meiru Song, Yijian Chen, Dong Wang, Yunmei Huang, Ping Hu, Chen He, Tao Dai, Lei Zhang, Mingdong Huang, Zhuo Chen, Peng Xu

Journal of colloid and interface science 2023 Sep 15

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Supramolecular assemblies fabricated by peptide-photosensitizer conjugates have attracted increasing attentions in recent years as drug carriers for chemotherapeutics (CTs). However, these assemblies have been known to suffer from disintegration by serum components leading to off-target drug release, and thereby impairing antitumor effects and causing systemic toxicities. To address this problem, this study reports a nano-architectural self-assembly peptide-photosensitizer carrier (NSPC) fabricated by conjugating a phthalocyanine derivative (MCPZnPc) and ε-poly-l-lysine (EPL). By engineering the core and peripheral interactions, MCPZnPC-EPL (M-E) NSPC firmly encapsulated multiple CTs, creating CT@M-E NSPCs that were highly stable against disintegration in serum. More importantly, CT@M-E NSPCs exhibited controlled release of CTs in tumor tissues. The antitumor effects of CTs were further promoted by the synergism with the reactivated photodynamic effect. Furthermore, M-E NSPC-encapsulation optimized CTs' biodistribution reducing adverse effects in vivo. This study provides a serum-stable supramolecular drug delivery system with photodynamic effect, which is applicable for a broad-range of CTs to promote antitumor effects and ameliorate adverse effects. Copyright © 2023 Elsevier Inc. All rights reserved.

Citation

Jincan Chen, Yang Zhou, Meiru Song, Yijian Chen, Dong Wang, Yunmei Huang, Ping Hu, Chen He, Tao Dai, Lei Zhang, Mingdong Huang, Zhuo Chen, Peng Xu. A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate. Journal of colloid and interface science. 2023 Sep 15;646:959-969