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    To explore the new iodine labeling method of nanomaterials, graphene oxide (GO) was labeled by 131I with AgI nanoparticles. As a control, GO was also labeled by 131I with chloramine-T method. The stability of the two 131I labeling materials, viz. [131I]AgI-GO and [131I]I-GO was evaluated. The results show that [131I]AgI-GO is very stable in inorganic environment such as PBS and saline. However, it is not stable enough in serum. The instability of [131I]AgI-GO in serum can be attributed to the higher affinity of Ag to S of thiol group in cysteine than iodine ions and much more chance of interaction between thiol group and [131I]AgI nanoparticles on two-dimensional GO than in three-dimensional nanomaterials. Copyright © 2023 Elsevier Ltd. All rights reserved.


    Hu Song, Guanquan Wang, Jing Wang, Xia Yang, Hongyuan Wei, Yuchuan Yang. Labeling of graphene oxide with [131I]AgI and its stability analysis. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2023 Aug;198:110862

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    PMID: 37235986

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