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    The first example of catalytic thiocarbonylation of aryl iodides using CO2 has been achieved employing a combination of PdCl2 and carbazole-derived phosphine ligands. Under mild conditions, a broad scope of aryl iodides were converted to the desired thioester products in the presence of aryl or alkyl thiols (33 examples, up to 96% yields). The choice of metal, ligands, and reductant were crucial for high efficiency and chemoselectivity. Moreover, this strategy provided an effective method for the late-stage functionalization of biorelevant molecules.


    Huan Wang, Yudong Li, Yajun Sun, Yuehui Li. Palladium-Catalyzed Thiocarbonylation of Aryl Iodides Using CO2. The Journal of organic chemistry. 2023 Jul 07;88(13):8835-8842

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    PMID: 37246751

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