Correlation Engine 2.0
Clear Search sequence regions

  • blood (1)
  • chest wall (10)
  • humans (1)
  • lung (5)
  • patients (7)
  • serum (2)
  • SP B (1)
  • SP C (1)
  • sp d (1)
  • surfactants (2)
  • Sizes of these terms reflect their relevance to your search.

    High-frequency chest wall oscillation (HFCWO) has been widely recognized for its airway secretion clearance effectiveness in critically ill ICU patients. The purpose of this randomized controlled trial is to validate and compare the effects of different frequencies of HFCWO on oxygenation, lung compliance, and pulmonary surfactant proteins (SPs) in critically ill patients admitted to the intensive care unit (ICU). Sixty patients with severe craniocerebral injury treated with a tracheostomy and mechanical ventilation were randomized into three groups (20 patients in each group): a single group (treated with 30 minutes of HFCWO once daily) and a double group (treated with 30 minutes of HFCWO twice daily), and a blank group (treated without HFCWO). Primary outcome measures included results on several specific proteins (SP-A, SP-B, SP-C, and SP-D) in serum and alveolar lavage fluid. Secondary outcome measures were lung static compliance test and oxygenation. Patients in both the single and double groups exhibited significant oxygenation and static compliance improvement. Similar results were observed in changes in SPs concentrations in the alveolar lavage fluid. However, a significant reduction of SPs levels was observed in the serum. In the group comparison analysis for the same variables between the single and double group, twice daily HFCWO treatments showed a significantly better result. Compared with HFCWO once daily, HFCWO twice daily is advantageous in patients with tracheostomy and prolonged ventilation, which demonstrated significantly greater effectiveness in improving oxygenation and lung static compliance linked to the increase of and SPs contents in the airways as well as a reduction of SPs shift from airways to the blood. Copyright © 2023 Elsevier Inc. All rights reserved.


    Jiaqi Ge, Yinjie Ye, Yongfei Tan, Fang Liu, Yan Jiang, Junjie Lu. High-frequency chest wall oscillation multiple times daily can better reduce the loss of pulmonary surfactant and improve lung compliance in mechanically ventilated patients. Heart & lung : the journal of critical care. 2023 Sep-Oct;61:114-119

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 37247538

    View Full Text