Damaris-Cristina Gheorghe, Raluca-Ioana Stefan-Van Staden, Ruxandra-Maria Ilie-Mihai, Paula Sfirloaga
Nanotechnology 2023 Jun 12Nanographene andα-cyclodextrin based sensors modified with gold nanoparticles and spheroidal copper were used to develop two stochastic sensors, which were then characterized and validated for the purpose of molecularly identifying and quantifying HER3 and HER4 in biological samples. In order to accomplish this goal, each of the stochastic sensors was incorporated in a nanoplatform. The two nanoplatforms were connected to a smartphone and recorded very low limits of determination (1 × 10-15g ml-1) and wide linear concentration ranges (1 × 10-15-1 × 10-8g ml-1) when a potential of 170 mV versus Ag/AgCl was applied. This allowed for the molecular identification and quantification of HER3 and HER4 in patients with gastric cancer, as well as in healthy individuals. © 2023 IOP Publishing Ltd.
Damaris-Cristina Gheorghe, Raluca-Ioana Stefan-Van Staden, Ruxandra-Maria Ilie-Mihai, Paula Sfirloaga. Nanoplatform-based analysis for the detection of HER3 and HER4 for gastric cancer diagnosis. Nanotechnology. 2023 Jun 12;34(34)
PMID: 37253333
View Full Text