Cascade Nucleophilic Addition-Cyclic Michael Addition of Arynes and Indoles Bearing Michael Acceptor: A Strategy to Construct Pyrroloacridines and Study of Their Physicochemical Properties.

A facile synthetic approach to 6H-pyrrolo[3,2,1-de]acridines has been developed by using cascade N-nucleophilic addition-cyclic Michael addition process of arynes and indoles substituted with Michael acceptors under metal-free conditions. Additionally, photophysical studies of a few of the newly synthesized pyrroloacridine compounds indicated good fluorescence emission properties.

Citation

Gurupada Hazra, Sayantan Kundu, Rambabu Dandela, Barla Thirupathi. Cascade Nucleophilic Addition-Cyclic Michael Addition of Arynes and Indoles Bearing Michael Acceptor: A Strategy to Construct Pyrroloacridines and Study of Their Physicochemical Properties. The Journal of organic chemistry. 2023 Jul 07;88(13):8493-8504

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PMID: 37259950

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