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    In most adult tissues, arginine is the precursor to polyamines, poly-cationic metabolites that interact with negatively charged biomolecules like DNA. Lee et al.1 discovered that pancreatic cancers synthesize polyamines from glutamine, illuminating a new pathway and underscoring their metabolic flexibility. Copyright © 2023 Elsevier Inc. All rights reserved.


    Dominik Awad, Costas A Lyssiotis. An unexpected pathway to polyamines in pancreatic cancer. Molecular cell. 2023 Jun 01;83(11):1765-1766

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    PMID: 37267902

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