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Thyroid carcinoma is the most common endocrine cancer which may manifest with unusual presentations. We addressed distant metastases as the first presentations of thyroid carcinoma in several patients, though previously considered to occur rarely. In this case series, 10 patients are introduced with signs and symptoms of distant metastasis. Detailed history, physical examination, laboratory data, and histopathologic final report of thyroid cancer are presented. Although it seems unusual to discover a distant metastasis without abnormal thyroid examination, several reports of similar findings urge the need to improve screening process. It is prudent to bear in mind these presentations for early detection of thyroid carcinoma. © Association of Otolaryngologists of India 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.


Mohammad Talebpour, Hossein Zabihi Mahmoudabadi, Khosrow Najjari, Reza Hajebi, Ehsan Rahimpour, Maryam Bahreini. Distant Metastasis as the First Presentation of Thyroid Carcinoma. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India. 2023 Jun;75(2):1020-1023

PMID: 37275079

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