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    Objective: Our objective is to investigate the risk factors and predictive ability of severe diabetic foot (DF) and diabetic foot ulcers (DFUs). Patients & methods: The efficacy of cystatin C in predicting the recurrence of DF and DFU was evaluated using a receiver operating characteristic curve. Results: The findings indicate that, in contrast to non-severe patients, severe cases exhibit elevated levels of cystatin C (p < 0.05). Additionally, a statistically significant increase in cystatin C levels was observed in the subgroup of patients with recurrent DFU (p < 0.01). Conclusion: Cystatin C emerged as a significant risk factor for severe DF and recurrent DFU, with the potential for predicting their occurrence.


    Jingsi An, Hongwei Yu, Zhenyu Gao, Xiangka Hu, Xueying Wang. Value of cystatin C in predicting recurrence in patients with severe diabetic foot and diabetic foot ulcer. Biomarkers in medicine. 2023 Mar;17(5):287-296

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    PMID: 37283546

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