Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy.

Background: Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates tumor cells by triggering high-energy radiation within cancer cells. Aim: In vivo evaluation of poly(vinyl alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. Materials & methods: PVA/BA NPs were synthesized and intravenously injected into tumor-bearing mice for BNCT. Results: The in vitro boron uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful BNCT. In an in vivo study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically used boronophenylalanine for oral cancer in a murine model. Conclusion: PVA/BA NPs exhibited effective therapeutic results for oral cancer treatments in BNCT.

Citation

Wei-Jen Chan, Sasinan Bupphathong, Han-Lin Cho, Venkanagouda S Goudar, Sina Dehestani, Chi-Shiun Chiang, Fan-Gang Tseng. Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy. Nanomedicine (London, England). 2023 Apr;18(9):743-754

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PMID: 37306216

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