Groebke-Blackburn-Bienaymé Reaction for DNA-Encoded Library Technology.

This study presents a DNA-compatible synthesis of diverse 5-arylimidazo[1,2-a]pyridin-3-amine derivatives using the Suzuki-Miyaura reaction, followed by a Groebke-Blackburn-Bienaymé (GBB) reaction. The GBB reaction demonstrates a wide substrate scope, mild one-pot reaction conditions, and compatibility with subsequent enzymatic ligation, highlighting its potential in DNA-encoded library technology.

Citation

Yujin An, Juyeon Lee, Hyewon Seo, Seri Bae, Jihee Kang, Jieon Lee, Jinwoo Kim, Myung Hee Nam, Minsoo Song, Gil Tae Hwang. Groebke-Blackburn-Bienaymé Reaction for DNA-Encoded Library Technology. Organic letters. 2023 Jun 23;25(24):4445-4450

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PMID: 37310879

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