Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm.

Nanthaya Tisavipat, Bryce K Chang, Farwa Ali, Sean J Pittock, Ryan Kammeyer, Anthony Declusin, Samuel J Cohn, Eoin P Flanagan

Neurology(R) neuroimmunology & neuroinflammation 2023 Jul

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Jaw dystonia and laryngospasm in the context of subacute brainstem dysfunction have been described in a small number of diseases, including antineuronal nuclear antibody type 2 (ANNA-2, also known as anti-Ri) paraneoplastic neurologic syndrome. Severe episodes of laryngospasms causing cyanosis are potentially fatal. Jaw dystonia can also cause eating difficulty, resulting in severe weight loss and malnutrition. In this report, we highlight the multidisciplinary management of this syndrome associated with ANNA-2/anti-Ri paraneoplastic neurologic syndrome and discuss its pathogenesis. Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Citation

Nanthaya Tisavipat, Bryce K Chang, Farwa Ali, Sean J Pittock, Ryan Kammeyer, Anthony Declusin, Samuel J Cohn, Eoin P Flanagan. Subacute Horizontal Diplopia, Jaw Dystonia, and Laryngospasm. Neurology(R) neuroimmunology & neuroinflammation. 2023 Jul;10(4)