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Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion. Copyright © 2023 Elsevier Inc. All rights reserved.
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Matthew Brown, Michelle A Tran, Nina Bhardwaj. Cancer immunity derailed: PGE2 misconducts cDC1s. Immunity. 2023 Jun 13;56(6):1165-1167
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PMID: 37315532
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