Correlation Engine 2.0
Clear Search sequence regions

  • antibiosis (1)
  • citrus (3)
  • fruit (1)
  • help (2)
  • kind (1)
  • limonins (2)
  • limonins (2)
  • research (1)
  • terpenoids (1)
  • Sizes of these terms reflect their relevance to your search.

    Limonoids are a class of oxygenated terpenoids that exist mainly in citrus fruits. As a kind of limonoid, obacunone has attracted more and more researchers' attention because of its extensive pharmacological activities. The purpose of the narrative review is to systematically review relevant studies on the pharmacological effects and pharmacokinetic characteristics of obacunone to provide researchers with the latest and useful information. Pharmacological studies have shown that obacunone has a variety of pharmacological activities, such as anticancer, antioxidant, anti-inflammatory, anti-diabetes, neuroprotection, antibiosis, and antivirus. Among them, the anticancer effect is the most prominent. Pharmacokinetic studies have shown that the oral bioavailability of obacunone is low. This indicates the presence of high first-pass metabolism. We hope that this paper can help relevant scholars understand the progress in pharmacological and pharmacokinetic research of obacunone and help the further development of obacunone as a functional food. Copyright © 2023. Published by Elsevier B.V.


    Wenhao Zheng, Shi Yang, Xin Chen. The pharmacological and pharmacokinetic properties of obacunone from citrus fruits: A comprehensive narrative review. Fitoterapia. 2023 Sep;169:105569

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 37315716

    View Full Text