Nanoparticles loaded with Daunorubicin as an advanced tool for cancer therapy.

Mehrab Pourmadadi, Amirhossein Ghaemi, Amin Shamsabadipour, Maryam Rajabzadeh-Khosroshahi, Meysam Shaghaghi, Abbas Rahdar, Sadanand Pandey

European journal of medicinal chemistry 2023 Oct 05

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Nowadays, with the advent of cutting-edge technologies in the field of biotechnology, some highly advanced medical methods are introduced to treat cancers more efficiently. In the chemotherapy processes, anti-cancer drugs can be encapsulated in a stimuli-responsive coating which is capable of being functionalized by diverse ligands to increase the biocompatibility and control drug release behavior in a targeted drug delivery system. Nanoparticles (NPs) are playing an important role as nanocarriers in chemotherapy procedures, recently, numerous novel drug delivery systems have been studied which employed diverse types of NPs with remarkable structural features like porous nanocarriers with active and extended surface areas to enhance the drug loading and delivery efficacy. In this study, Daunorubicin (DAU) as an effective anti-cancer drug for treating various cancers introduced, and its application for novel drug delivery systems either as a single chemotherapy agent or co-delivery alongside other drugs with diverse NPs has been reviewed. Copyright © 2023 Elsevier Masson SAS. All rights reserved.

Citation

Mehrab Pourmadadi, Amirhossein Ghaemi, Amin Shamsabadipour, Maryam Rajabzadeh-Khosroshahi, Meysam Shaghaghi, Abbas Rahdar, Sadanand Pandey. Nanoparticles loaded with Daunorubicin as an advanced tool for cancer therapy. European journal of medicinal chemistry. 2023 Oct 05;258:115547