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A simple, mild, metal-free catalytic protocol is developed to convert amides to amines. This protocol uses a stable tetrabutylammonium difluorotriphenylsilicate in combination with silanes that generates a highly reactive hydrosilicate species, which enables the reduction of a broad range of amides to amines in moderate to good yields. The attractive features of this protocol include operational simplicity, safety, short reaction times, room temperature reaction, broad substrate scope, and amenable to scale up.


Vinothkumar Vinayagam, Subir Kumar Sadhukhan, Satish Kumar Karre, Ravuri Srinath, Ravi Kumar Maroju, Purushotham Reddy Karra, Hema Sundar Naveen Babu Bathula, Siva Kundrapu, Srikanth Reddy Surukonti. TBAT-Catalyzed Deoxygenative Reduction of Tertiary Amides to Amines. Organic letters. 2023 Jun 30;25(25):4610-4614

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PMID: 37338092

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