Effect of Glycyrrhetic Acid Derivatives on Regulation of Thymocyte Volume.

M B Rakhimova, R S Esanov, P G Merzlyak, M B Gafurov, R Sh Kurbannazarova, O D Matchanov, R Z Sabirov

Bulletin of experimental biology and medicine 2023 May

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We studied the effects of glycyrrhetinic acid (bioactive aglycone of glycyrrhizin) and its ester derivatives at positions C-3 and C-30 on the cell volume regulation in rat thymocytes under conditions of hypoosmotic stress. Native glycyrrhetinic acid completely suppressed this process with half-maximal concentration of 12.7±1.4 μM and Hill coefficient of 3.1±0.6. Formation of esters at C-3 (esters with the acetic, cinnamic and methoxi-cinnamic acid) and at C-30 (methyl ester) drastically decreased the inhibitory activity of the molecule, suggesting that intact hydroxyl group at C-3 and carboxyl group at C-30 are structurally important determinants of biological activity of glycyrrhetinic acid towards volume regulation of thymic lymphocytes. © 2023. Springer Science+Business Media, LLC, part of Springer Nature.

Citation

M B Rakhimova, R S Esanov, P G Merzlyak, M B Gafurov, R Sh Kurbannazarova, O D Matchanov, R Z Sabirov. Effect of Glycyrrhetic Acid Derivatives on Regulation of Thymocyte Volume. Bulletin of experimental biology and medicine. 2023 May;175(1):27-31