The Transfer of Domperidone into Human Milk Remains Low at High Doses.

Domperidone is a dopamine-2 (D2) receptor antagonist that stimulates the release of stored prolactin in the anterior pituitary. It is prescribed off-label in Canada and Australia to promote lactation in prolactin-deficient women. The case of a 43-year-old woman taking a high daily dose of domperidone (160 mg) is described from the InfantRisk Center Human Milk Biorepository. Milk samples were analyzed using a high-performance liquid chromatography-mass spectrometry method, detecting an average domperidone concentration of 7.0 ng/mL (range 6.2 to 8.4 ng/mL). Even at high doses, the transfer of domperidone into breast milk was negligible with a relative infant dose (RID) of 0.05%. The RID estimates the infant's potential exposure to a drug via lactation as a percentage of the weight-adjusted maternal dose. The standard threshold for reasonable infant exposure is an RID of 10%.

Citation

Kaytlin Krutsch, Palika Datta. The Transfer of Domperidone into Human Milk Remains Low at High Doses. Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine. 2023 Jul;18(7):555-556

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PMID: 37352416

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