Connecting the Dots: N6-Methyladenosine (m6 A) Modification in Spermatogenesis.

Mengya Zhang, Junyu Nie, Yufei Chen, Xiaofeng Li, Hao Chen

Advanced biology 2023 Aug

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N6-methyladenosine (m6 A) is the most common RNA modification found in eukaryotes and is involved in multiple biological processes, including neuronal development, tumorigenesis, and gametogenesis. It is well known that methylation-modifying enzymes (classified into writers, erasers, and readers) mediate catalysis, clearance, and recognition of m6 A. Recent studies suggest that these genes may be associated with spermatogenesis. Numerous studies have revealed the m6 A role during spermatogenesis. However, the expression patterns and relationships of these m6 A enzymes during various stages of spermatogenesis remain unknown. In this review, it is aimed to provide an overview of m6 A enzyme functions and elucidate their potential mechanisms and regulatory relationships at a specific phase during spermatogenesis, providing new insights into the m6 A modification underlying the spermatogenesis process. © 2023 Wiley-VCH GmbH.

Citation

Mengya Zhang, Junyu Nie, Yufei Chen, Xiaofeng Li, Hao Chen. Connecting the Dots: N6-Methyladenosine (m6 A) Modification in Spermatogenesis. Advanced biology. 2023 Aug;7(8):e2300068