Animal models of kidney iron overload and ferroptosis: a review of the literature.

Mónica Ríos-Silva, Yolitzy Cárdenas, Alan Gabriel Ortega-Macías, Xóchitl Trujillo, Efrén Murillo-Zamora, Oliver Mendoza-Cano, Jaime Alberto Bricio-Barrios, Isabel Ibarra, Miguel Huerta

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2023 Dec

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In recent years, it has been identified that excess iron contributes to the development of various pathologies and their complications. Kidney diseases do not escape the toxic effects of iron, and ferroptosis is identified as a pathophysiological mechanism that could be a therapeutic target to avoid damage or progression of kidney disease. Ferroptosis is cell death associated with iron-dependent oxidative stress. To study the effects of iron overload (IOL) in the kidney, numerous animal models have been developed. The methodological differences between these models should reflect the IOL-generating mechanisms associated with human IOL diseases. A careful choice of animal model should be considered for translational purposes. © 2023. The Author(s), under exclusive licence to Springer Nature B.V.

Citation

Mónica Ríos-Silva, Yolitzy Cárdenas, Alan Gabriel Ortega-Macías, Xóchitl Trujillo, Efrén Murillo-Zamora, Oliver Mendoza-Cano, Jaime Alberto Bricio-Barrios, Isabel Ibarra, Miguel Huerta. Animal models of kidney iron overload and ferroptosis: a review of the literature. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2023 Dec;36(6):1173-1187