Effect of Globin Digests on Physical Fatigue in Mice.

Osamu Nakagawasai, Kotaro Yamada, Kohei Takahashi, Yuko Oshima, Sena Hayasaka, Kazuaki Shoji, Wataru Nemoto, Koichi Tan-No

Biological & pharmaceutical bulletin 2023

filter terms:

Globin digest (GD) inhibits dietary hypertriglyceridemia; however, its effects on physical fatigue remain unknown. Therefore, this study aimed to investigate the potential anti-fatigue effects of GD. Repeated administration of GD and valine (Val)-Val-tyrosine (Tyr)-proline (Pro), a component of GD, for five days prevented the forced walking-induced decrease in locomotion. Furthermore, GD treatment reversed the forced walking-induced increase in blood lactate levels in mice and increased phosphorylated AMP-activated protein kinase (p-AMPK) in the soleus muscle, suggesting that the anti-fatigue effect of GD involves AMPK activation in the soleus muscle through reduced blood lactate.

Citation

Osamu Nakagawasai, Kotaro Yamada, Kohei Takahashi, Yuko Oshima, Sena Hayasaka, Kazuaki Shoji, Wataru Nemoto, Koichi Tan-No. Effect of Globin Digests on Physical Fatigue in Mice. Biological & pharmaceutical bulletin. 2023;46(7):1027-1030