Correlation Engine 2.0
Clear Search sequence regions

  • cellular (1)
  • contrast agents (10)
  • diagnosis (1)
  • ferritin (3)
  • helps (1)
  • human body (1)
  • humans (1)
  • research (1)
  • Sizes of these terms reflect their relevance to your search.

    Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.


    Qing Dan, Xinpeng Jiang, Run Wang, Zhifei Dai, Desheng Sun. Biogenic Imaging Contrast Agents. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Sep;10(25):e2207090

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 37401173

    View Full Text