Glycyrrhiza polysaccharides inhibits PRRSV replication.

Youbing Yang, Yongjian Liu, Ran Lou, Ying Lei, Gan Li, Zhiqian Xu, Xiangbin You

Virology journal 2023 Jul 05

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Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteriviridae family, with a high rate of variation and has caused huge economic losses to the pig industry in various countries since its discovery. Our results show that GCP can inhibit PRRSV replication in a dose-dependent manner. Furthermore, GCP could inhibit the mRNA expression of receptor genes CD163 and NF-κB p65 and promote the mRNA expression of the SLA-7 gene. Because of these results, GCP can be used as a candidate drug to prevent and treat PRRS. © 2023. The Author(s).

Citation

Youbing Yang, Yongjian Liu, Ran Lou, Ying Lei, Gan Li, Zhiqian Xu, Xiangbin You. Glycyrrhiza polysaccharides inhibits PRRSV replication. Virology journal. 2023 Jul 05;20(1):140