Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes.

Kyu Hee Park, Yoon Ji Choi, Won Kee Min, Sun Hwa Lee, Jaeyoung Kim, Sang Hoon Jeong, Ju-Han Lee, Byung Min Choi, Suhyun Kim

Ecotoxicology and environmental safety 2023 Sep 15

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Air pollution is a risk factor that increases cardiovascular morbidity and mortality. In this study, we investigated the cardiotoxicity of particulate matter (PM) exposure using a zebrafish embryo model. We found that PM exposure induced cardiotoxicity, such as arrhythmia, during cardiac development. PM exposure caused cardiotoxicity by altering the expression levels of cardiac development (T-box transcription factor 20, natriuretic peptide A, and GATA-binding protein 4)- and ion-channel (scn5lab, kcnq1, kcnh2a/b, and kcnh6a/b)-related genes. In conclusion, this study showed that PM induces the aberrant expression of cardiac development- and ion channel-related genes, leading to arrhythmia-like cardiotoxicity in zebrafish embryos. Our study provides a foundation for further research on the molecular and genetic mechanisms of cardiotoxicity induced by PM exposure. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Kyu Hee Park, Yoon Ji Choi, Won Kee Min, Sun Hwa Lee, Jaeyoung Kim, Sang Hoon Jeong, Ju-Han Lee, Byung Min Choi, Suhyun Kim. Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes. Ecotoxicology and environmental safety. 2023 Sep 15;263:115201