What can ex vivo experiments contribute to clinical haemostasis management?

Keyvan Karkouti, Peter L Gross

British journal of anaesthesia 2023 Sep

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A recent ex vivo study found that post-cardiopulmonary bypass platelet defects can be restored with supplemental fibrinogen, but the clinical significance of this finding will require further study. We propose that the best management strategy for achieving haemostasis in bleeding surgical patients is to identify individualised coagulation defects and then use a targeted therapeutic approach that addresses each identified defect systematically. Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

Citation

Keyvan Karkouti, Peter L Gross. What can ex vivo experiments contribute to clinical haemostasis management? British journal of anaesthesia. 2023 Sep;131(3):424-425