Low ceruloplasmin levels exacerbate retinal degeneration in a hereditary hemochromatosis model.

Brandon D Anderson, Timothy Lee, Brent Bell, Ying Song, Joshua L Dunaief

Disease models & mechanisms 2023 Jul 01

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In a previous report, a 39-year-old patient with high serum iron levels from hereditary hemochromatosis (HH) was diagnosed with a form of retinal degeneration called bull's eye maculopathy. This is atypical for patients with HH, so it was theorized that the low serum levels of ferroxidase ceruloplasmin (CP) of this patient coupled with the high iron levels led to the retinal degeneration. CP, by oxidizing iron from its ferrous to ferric form, helps prevent the oxidative damage caused by ferrous iron. To test this, a hepcidin knockout (KO) mouse model of HH was combined with Cp KO to test whether the combination would lead to more severe retinal degeneration. Monthly in vivo retinal images were acquired and, after 11 months, mice were euthanized for further analyses. Both heterozygous and homozygous Cp KO increased the rate and severity of retinal degeneration. These results demonstrate the protective role of CP, which is most likely owing to its ferroxidase activity. The findings suggest that CP levels may influence the severity of retinal degeneration, especially in individuals with high serum iron. © 2023. Published by The Company of Biologists Ltd.

Citation

Brandon D Anderson, Timothy Lee, Brent Bell, Ying Song, Joshua L Dunaief. Low ceruloplasmin levels exacerbate retinal degeneration in a hereditary hemochromatosis model. Disease models & mechanisms. 2023 Jul 01;16(7)