HNRNPU's multi-tasking is essential for proper cortical development.

Tamar Sapir, Orly Reiner

BioEssays : news and reviews in molecular, cellular and developmental biology 2023 Sep

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Heterogeneous nuclear ribonucleoprotein U (HNRNPU) is a nuclear protein that plays a crucial role in various biological functions, such as RNA splicing and chromatin organization. HNRNPU/scaffold attachment factor A (SAF-A) activities are essential for regulating gene expression, DNA replication, genome integrity, and mitotic fidelity. These functions are critical to ensure the robustness of developmental processes, particularly those involved in shaping the human brain. As a result, HNRNPU is associated with various neurodevelopmental disorders (HNRNPU-related neurodevelopmental disorder, HNRNPU-NDD) characterized by developmental delay and intellectual disability. Our research demonstrates that the loss of HNRNPU function results in the death of both neural progenitor cells and post-mitotic neurons, with a higher sensitivity observed in the former. We reported that HNRNPU truncation leads to the dysregulation of gene expression and alternative splicing of genes that converge on several signaling pathways, some of which are likely to be involved in the pathology of HNRNPU-related NDD. © 2023 The Authors. BioEssays published by Wiley Periodicals LLC.

Citation

Tamar Sapir, Orly Reiner. HNRNPU's multi-tasking is essential for proper cortical development. BioEssays : news and reviews in molecular, cellular and developmental biology. 2023 Sep;45(9):e2300039