Morphological and Functional Comparison of Mice Models for Retinitis Pigmentosa.

Prakadeeswari Gopalakrishnan, Avigail Beryozkin, Eyal Banin, Dror Sharon

Advances in experimental medicine and biology 2023

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Retinitis pigmentosa (RP) is the predominant form of inherited retinal degenerations (IRDs) caused by abnormalities and loss of photoreceptor cells ensuing diminishment of vision. RP is a heterogenous genetic disorder associated with mutations in over 80 genes, showing various inheritance patterns. Laboratory mouse models are important for our understanding of disease mechanisms, modifier effects, and development of therapeutic modalities. In this review, we have summarized a comprehensive comparison of our previously reported Fam161a knockout (KO) mouse model with other well-studied RP mouse models, Fam161aGT/GT, Pde6brd1, Nr2e3rd7, Rpgrrd9, and Pde6brd10 using structural and functional analysis of the retina. Fam161atm1b/tm1b mouse models are important for developing novel therapies and mainly AAV-based gene therapy and translational read-through-inducing drugs. © 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.

Citation

Prakadeeswari Gopalakrishnan, Avigail Beryozkin, Eyal Banin, Dror Sharon. Morphological and Functional Comparison of Mice Models for Retinitis Pigmentosa. Advances in experimental medicine and biology. 2023;1415:365-370