Correlation Engine 2.0
Clear Search sequence regions

  • humans (1)
  • isomer (1)
  • lutein (6)
  • macula lutea (2)
  • meso zeaxanthin (1)
  • pigments (2)
  • retina (5)
  • zeaxanthin (7)
  • Sizes of these terms reflect their relevance to your search.

    Zeaxanthin and lutein are xanthophyll pigments present in the human retina and particularly concentrated in its center referred to as the yellow spot (macula lutea). The fact that zeaxanthin, including its isomer meso-zeaxanthin, is concentrated in the central part of the retina, in contrast to lutein also present in the peripheral regions, raises questions about the possible physiological significance of such a heterogeneous distribution of macular xanthophylls. Here, we attempt to address this problem using resonance Raman spectroscopy and confocal imaging, with different laser lines selected to effectively distinguish the spectral contribution of lutein and zeaxanthin. Additionally, fluorescence lifetime imaging microscopy (FLIM) is used to solve the problem of xanthophyll localization in the axon membranes. The obtained results allow us to conclude that one of the key advantages of a particularly high concentration of zeaxanthin in the central part of the retina is the high efficiency of this pigment in the dynamic filtration of light with excessive intensity, potentially harmful for the photoreceptors.


    Wojciech Grudzinski, Rafal Luchowski, Jan Ostrowski, Alicja Sęk, Maria Manuela Mendes Pinto, Renata Welc-Stanowska, Monika Zubik-Duda, Grzegorz Teresiński, Robert Rejdak, Wieslaw I Gruszecki. Physiological Significance of the Heterogeneous Distribution of Zeaxanthin and Lutein in the Retina of the Human Eye. International journal of molecular sciences. 2023 Jun 27;24(13)

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 37445880

    View Full Text