Rituximab for treatment of pachymeningitis in granulomatosis with polyangiitis.

Aditi Patankar, Sandeep Yadav, Canchi Balakrishnan, Sahana Baliga

BMJ case reports 2023 Jul 14

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Pachymeningitis is a rare manifestation of granulomatosis with polyangiitis (GPA), and there is a paucity of literature regarding the efficiency of rituximab (RTX) in such cases. We present a woman in her early 50s with GPA who initially responded adequately to conventional therapy. However, the treatment course was complicated by pulmonary cryptococcosis. The patient later developed non-infectious pachymeningitis, which failed to respond to steroids and methotrexate. However, using RTX upfront led to good clinical response and radiological resolution. © BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.

Citation

Aditi Patankar, Sandeep Yadav, Canchi Balakrishnan, Sahana Baliga. Rituximab for treatment of pachymeningitis in granulomatosis with polyangiitis. BMJ case reports. 2023 Jul 14;16(7)