Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases.

Yani Lin, Liyuan Ran, Ximing Du, Hongyuan Yang, Yingjie Wu

Biochimica et biophysica acta. Molecular and cell biology of lipids 2023 Sep

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Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts health and disease remain to be elucidated. In this review, we first summarize the structural characteristics and lipid transport functions of OSBP, and then focus on recent progresses linking OSBP with fatty liver disease, diabetes, lysosome-related diseases, cancer and viral infections, with the aim of discovering novel therapeutic strategies for common human diseases. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Yani Lin, Liyuan Ran, Ximing Du, Hongyuan Yang, Yingjie Wu. Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2023 Sep;1868(9):159365