Cross-talk between zinc and calcium regulates ion transport: A role for the zinc receptor, ZnR/GPR39.

Zinc is essential for many physiological functions, with a major role in digestive system, skin health, and learning and memory. On the cellular level, zinc is involved in cell proliferation and cell death. A selective zinc sensing receptor, ZnR/GPR39 is a Gq-coupled receptor that acts via the inositol trisphosphate pathway to release intracellular Ca2+ . The ZnR/GPR39 serves as a mediator between extracellular changes in Zn2+ concentration and cellular Ca2+ signalling. This signalling pathway regulates ion transporters activity and thereby controls the formation of transepithelial gradients or neuronal membrane potential, which play a fundamental role in the physiological function of these tissues. This review focuses on the role of Ca2+ signalling, and specifically ZnR/GPR39, with respect to the regulation of the Na+ /H+ exchanger, NHE1, and of the K+ /Cl- cotransporters, KCC1-3, and also describes the physiological implications of this regulation. © 2023 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.

Citation

Michal Hershfinkel. Cross-talk between zinc and calcium regulates ion transport: A role for the zinc receptor, ZnR/GPR39. The Journal of physiology. 2023 Jul 18

PMID: 37462604

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