BaseSpace
Correlation Engine 2.0
Import Your Data
Literature

FAQ

More FAQs

Back to top
Clear Search sequence regions
(e.g. G-protein-coupled receptor binding, Inflammatory disorder, Retina, Alcohol, Aspirin)
Bookmark Forward

Decoding the mystery of MMTV-like virus and its relationship with breast cancer metastasis.

Hafiz Fawad Khalid, Sadia Bibi, Amjad Ali, Nida Fawad, Muhammad Usman Shams, Wafa Idrees, Muhammad Waqas, Shazia Rafique, Abbas Khan, Faizullah Khan, Fahad Nasser Almajhdi

Journal of infection and public health 2023 Sep


filter terms:
  • breast cancer (5)
  • breast metastasis (3)
  • breast neoplasms (1)
  • env gene (4)
  • female (1)
  • forms breast (1)
  • genes env (2)
  • humans (1)
  • like (8)
  • metastasis (3)
  • mice (2)
  • MMTV (9)
  • patient (2)
  • pcr (1)
  • phenotypes (1)
  • tumor virus (1)
    • Sizes of these terms reflect their relevance to your search.

    MMTV causes mammary tumors in mice, and it is associated with invasive and aggressive forms of breast cancer in humans. However, the underlying mechanisms are yet unknown. We aimed to determine the MMTV-like virus (MMTV-LV) association with histological types of breast cancer, nodal involvement, and metastasis. First, 105 breast cancer biopsies and 15 disease-free biopsies were collected. Details of clinicopathological characteristics were retrieved from patients' records. The status of MMTV-LV was already known for these biopsy samples. Associations of MMTV-LV prevalence with LNM status and metastatic history were determined. Next, quantitative PCR (qPCR) was used to quantify env gene mRNA in biopsies positive for MMTV-LV. Expression of the env gene was compared against different histopathological types of mammary tumor, LNM status, and metastasis by performing Ordinary One Way ANOVA followed by Tukey's multiple comparisons test. MMTV-LV prevalence was found to have no significant association with LNM or metastatic history. As compared to normal control, expression of the env gene was significantly higher (>2.8 folds) in invasive samples (P-value: < 0.01). Expression was also higher (3.28 and 2.89 folds) in patient samples with LNM (P-value: 0.0006) or metastatic history (P-value: < 0.0001), respectively. We conclude that MMTV-LV prevalence is not associated with LNM status or breast cancer metastasis; samples with invasive phenotypes, nodal involvement, and metastasis exhibit significantly higher expression of the MMTV-like env gene. Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

    Citation

    Hafiz Fawad Khalid, Sadia Bibi, Amjad Ali, Nida Fawad, Muhammad Usman Shams, Wafa Idrees, Muhammad Waqas, Shazia Rafique, Abbas Khan, Faizullah Khan, Fahad Nasser Almajhdi. Decoding the mystery of MMTV-like virus and its relationship with breast cancer metastasis. Journal of infection and public health. 2023 Sep;16(9):1396-1402

    Expand section icon Mesh Tags


    PMID: 37480670

    View Full Text
    • Copyright © 2024 Illumina Inc. All rights reserved.