Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein.

Thayne H Dickey, Niraj H Tolia

Trends in parasitology 2023 Oct

filter terms:

Malaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity against blood-stage infection reduces parasitemia and disease severity. Duffy-binding protein (DBP) is the primary parasite protein responsible for the invasion of red blood cells and it is a leading subunit vaccine candidate. An effective vaccine, however, is still lacking despite decades of interest in DBP as a vaccine candidate. This review discusses the reasons for targeting DBP, the challenges associated with developing a vaccine, and modern structural vaccinology methods that could be used to create an effective DBP vaccine. Next-generation DBP vaccines have the potential to elicit a broadly protective immune response and provide durable and potent protection from P. vivax malaria. Copyright © 2023. Published by Elsevier Ltd.

Citation

Thayne H Dickey, Niraj H Tolia. Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein. Trends in parasitology. 2023 Oct;39(10):850-858