Recurrent Stroke with Rapid Development of Intracranial Artery Stenosis and Subsequent Successful Mechanical Thrombectomy in Essential Thrombocythemia.

Yuji Kato, Shohei Iijima, Shinya Kohyama, Tomoya Maeda, Tsugumi Sato, Shinichi Takahashi, Satoshi Suda

Internal medicine (Tokyo, Japan) 2024 Mar 15

filter terms:

Essential thrombocythemia is a myeloproliferative neoplasm. Ischemic stroke is frequently the first manifestation of essential thrombocythemia. We herein report a patient with JAK2V617 mutation-positive essential thrombocythemia who developed recurrent ischemic stroke with rapid development of intracranial artery stenosis and subsequently underwent successful mechanical thrombectomy. The high JAK2V617F allele burden in our patient (58.4%) may have affected the patient's condition. We discuss similar reports in the literature and the possible pathophysiologic mechanism of large artery involvement in these patients.

Citation

Yuji Kato, Shohei Iijima, Shinya Kohyama, Tomoya Maeda, Tsugumi Sato, Shinichi Takahashi, Satoshi Suda. Recurrent Stroke with Rapid Development of Intracranial Artery Stenosis and Subsequent Successful Mechanical Thrombectomy in Essential Thrombocythemia. Internal medicine (Tokyo, Japan). 2024 Mar 15;63(6):847-852