Smartphone-based pH responsive 3-channel colorimetric biosensor for non-enzymatic multi-antibiotic residues.

Xiaotian Zhou, Siyuan Fu, Jiahua Li, Yuhan Yi, Yaqi Hu, Ji Lu, Chao Yang, Jinfeng Miao, Yuanyuan Xu

Food chemistry 2023 Dec 15

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Antibiotic residues in animal-derived food pose a risk to food safety and human health. Here, a smartphone-based pH-responsive 3-channel colorimetric biosensor is constructed for rapid detection of non-enzymatic multi-antibiotic residues in milk. In this system, a magnetic separation and enrichment approach is designed to specifically capture different antibiotic residues in complex environment. Indicators loaded on polydopamine-silver nanoparticles with excellently pH responsive visualization properties are utilized to ensure the high sensitivity of detection system. Moreover, smartphones are introduced to fulfill the demand for portable and on-site inspection of practical applications. It achieves simultaneous detection of oxytetracycline, kanamycin and streptomycin in the linear range of 1-105 pg/mL with detection limits of 0.085, 0.168, and 0.307 pg/mL, respectively. The practicality of the reported multi-antibiotic residues detection system is successfully demonstrated and evaluated challenging milk samples. Therefore, this system demonstrates the wide applications in multi-antibiotic residue analysis and food safety guarantee. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Xiaotian Zhou, Siyuan Fu, Jiahua Li, Yuhan Yi, Yaqi Hu, Ji Lu, Chao Yang, Jinfeng Miao, Yuanyuan Xu. Smartphone-based pH responsive 3-channel colorimetric biosensor for non-enzymatic multi-antibiotic residues. Food chemistry. 2023 Dec 15;429:136953