Quality-by-design-based development of ultradeformable nanovesicular transgelosome of standardized Piper longum extract for melanoma.

Debadatta Mohapatra, Dulla Naveen Kumar, Singh Shreya, Dhananjay Panigrahi, Ashish Kumar Agrawal, Alakh N Sahu

Nanomedicine (London, England) 2023 Jun

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Background: Melanoma is the most aggressive and deadly form of skin cancer. The stratum corneum of the skin is a major obstacle to dermal and transdermal drug delivery. Ultradeformable nanovesicular transferosome has the capacity for deeper skin penetration and its incorporation into hydrogel forms a transgelosome that has better skin permeability and patient compliance. Method: Here, the quality-by-design-based development and optimization of nanovesicular transgelosome of standardized Piper longum fruit ethanolic extract (PLFEE) for melanoma therapy are reported. Results: Compared with standardized PLFEE-loaded plain gel, the transgelosome displayed optimal pharmaceutical properties and improved ex vivo skin permeability and in vivo tumor regression in B16F10 melanoma-bearing C57BL/6 mice. Conclusion: The results reflect the potential of transgelosome for melanoma therapy.

Citation

Debadatta Mohapatra, Dulla Naveen Kumar, Singh Shreya, Dhananjay Panigrahi, Ashish Kumar Agrawal, Alakh N Sahu. Quality-by-design-based development of ultradeformable nanovesicular transgelosome of standardized Piper longum extract for melanoma. Nanomedicine (London, England). 2023 Jun;18(14):963-985