Isothiocyanates as potential antifungal agents: a mini-review.

Rakesh K Sharma, Shivani B Patil, Ashwini K Jadhav, Sankunny M Karuppayil

Future microbiology 2023 Jul

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Cruciferous vegetables and mustard oil are rich in the glucosinolate group of molecules. Isothiocyanates are an important group of glucosinolate derivatives. These derivatives have various bioactive properties, including antioxidant, antibacterial, anticarcinogenic, antifungal, antiparasitic, herbicidal and antimutagenic activity. Previous studies indicate that regular intake of such vegetables may considerably reduce the incidence of various types of cancer. These studies have inspired studies where the bioactive agents of these plants have been isolated and explored for their therapeutic applications. The use of these bioactive compounds as antifungals could be a new therapeutic approach against human pathogenic fungi. Isothiocyanates have been studied for their antifungal activity and have the potential to be used for antifungal therapy.

Citation

Rakesh K Sharma, Shivani B Patil, Ashwini K Jadhav, Sankunny M Karuppayil. Isothiocyanates as potential antifungal agents: a mini-review. Future microbiology. 2023 Jul;18:673-679