Imaging application of an MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe.

Xinglu Zhou, Changmei Zhang, Qiquan Zhou, Jian Liang, Xiaoyan Zhang, Yujie Shi, Jingna Zhu, Lei Zhong

Journal of biomaterials applications 2023 Sep

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In recent years, the application of nanoimaging technology on standardize tumor diagnosis has become a new research hotspot, especially nanoprobes. Our research group has synthesized a kind of nanocarrier, mPEG2000-GPLGIAGQ-DSPE, which has the characteristic of matrix metalloproteinase-2 (MMP2) sensitive ability in tumor microenvironment. Meanwhile, the encapsulation method is adopted to prepare MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe with mPEG2000-GPLGIAGQ-DSPE as the carrier. On the one hand, this novel nanoprobe not only can effectively improve the solubility of prussian blue, but is non-toxic and safe for cells. On the other hand, octapeptide (GPLGIAGQ) in mPEG2000-GPLGIAGQ-DSPE nanocarrier can specifically respond to MMP2 in tumor cells to release prussian blue, and achieve targeted intelligent imaging of tumor cells.

Citation

Xinglu Zhou, Changmei Zhang, Qiquan Zhou, Jian Liang, Xiaoyan Zhang, Yujie Shi, Jingna Zhu, Lei Zhong. Imaging application of an MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe. Journal of biomaterials applications. 2023 Sep;38(3):372-380