Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

A nine-year-old, castrated male mixed-breed dog presented with a three-month history of sneezing and stertorous breathing. Computed tomography revealed a soft tissue mass in the left nasal cavity with lysis of the cribriform plate. The mass was diagnosed as intranasal sarcoma based on histopathological analysis. The tumor cells were immunohistochemically positive for KIT and platelet-derived growth factor receptor α/β and negative for vascular endothelial growth factor receptor 2 and cyclooxygenase-2. Treatment with toceranib phosphate (TOC) and firocoxib reduced the tumor size, which was defined as partial response (PR). After PR induction, TOC alone mediated survival for 205 days. This case report suggests that the combination of TOC and possibly firocoxib may be a therapeutic option for canine intranasal sarcoma.


Hironari Osada, Taiga Okazawa, Kazuya Kushida, Miori Kishimoto, Mitsuhiro Ikeda, Hirotaka Kondo, Junpei Kimura, Keitaro Ohmori. Toceranib phosphate and firocoxib-mediated partial response in a dog with advanced intranasal sarcoma. The Journal of veterinary medical science. 2023 Sep 20;85(9):1004-1009

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 37532540

View Full Text