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Unveiling TMEM106B: SARS-CoV-2's secret entrance to the cell.

Alexander Lacrampe, Fenghua Hu

Cell 2023 Aug 03


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    The lysosomal membrane protein TMEM106B functions as a proviral factor in SARS-CoV-2 infection, though it was not known how. In this issue of Cell, Baggen et al. demonstrate that TMEM106B serves as an ACE2-independent receptor for SARS-CoV-2 entry by promoting the fusion of the viral membrane with the lysosomal membrane. Copyright © 2023 Elsevier Inc. All rights reserved.

    Citation

    Alexander Lacrampe, Fenghua Hu. Unveiling TMEM106B: SARS-CoV-2's secret entrance to the cell. Cell. 2023 Aug 03;186(16):3329-3331

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    PMID: 37541193

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    • Copyright © 2024 Illumina Inc. All rights reserved.