Neurokinin 3 receptor antagonism for menopausal hot flashes.

Alexander N Comninos, Waljit S Dhillo

Cell 2023 Aug 03

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Menopausal hot flashes are common and debilitating. Menopausal Hormone Therapy (MHT) is effective for hot flashes but has risks and side effects that limit its use. NK3 receptor antagonism has emerged as a novel therapeutic strategy, leading to the recent FDA approval of fezolinetant, a first-in-class nonhormonal treatment for menopausal hot flashes. To view this Bench to Bedside, open or download the PDF. Copyright © 2023 Elsevier Inc. All rights reserved.