Prebiotic effect of poly-D-3-hydroxybutyrate prevents dyslipidemia in obese mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep

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Obesity is a global health problem caused by genetic, environmental, and psychological factors and is associated with various health disorders. As such, there is a growing focus on the prevention of obesity and related diseases. The gut microbiota plays a crucial role in these diseases and has become a therapeutic target. Prebiotics, such as poly-d-3-hydroxybutyric acid (PHB), have gained attention for their potential to alter the gut microbiota, promote beneficial bacterial growth, and alleviate obesity. In this study, we examined the prebiotic effects of PHB in obese mice. We found that, in C57BL/6N mice, PHB reduced blood lipid levels. Analysis of the intestinal microflora also revealed an increase in short-chain fatty acid-producing bacteria. When PHB was administered to obese mice, subcutaneous fat and dyslipidemia were reduced, and the number of beneficial bacteria in the intestinal microflora increased. Furthermore, fatty degradation and oxidative stress were suppressed in the liver. PHB regulates gut bacterial changes related to obesity and effectively inhibits dyslipidemia, suggesting that it could be a prebiotic agent for curing various obesity-related diseases. In summary, PHB increases the beneficial gut microbiota, leading to an alleviation of obesity-associated dyslipidemia. © 2023 Federation of American Societies for Experimental Biology.

Citation

Mayuko Mishima, Shiro Takeda, Masaki Nagane, Takehito Suzuki, Masaya Ogata, Ayaka Shima, Naoyuki Aihara, Junichi Kamiie, Rimina Suzuki, Hinano Mizugaki, Yuko Okamatsu-Ogura, Takumi Satoh, Tadashi Yamashita. Prebiotic effect of poly-D-3-hydroxybutyrate prevents dyslipidemia in obese mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 Sep;37(9):e23121