Microbes mediated immunogenic cell death in cancer immunotherapy.

Immunogenic cell death (ICD) is one of the 12 distinct cell death forms, which can trigger immune system to fight against cancer cells. During ICD, a number of cellular changes occur that can stimulate an immune response, including the release of molecules called damage-associated molecular patterns (DAMPs), signaling to immune cells to recognize and attack cancer cells. By virtue of their pivotal role in immune surveillance, ICD-based drug development has been a new approach to explore novel therapeutic combinations and personalized strategies in cancer therapy. Several small molecules and microbes can induce ICD-relevant signals and cause cancer cell death. In this review, we highlighted the role of microbe-mediate ICD in cancer immunotherapy and described the mechanisms through which microbes might serve as ICD inducers in cancer treatment. We also discussed current attempts to combine microbes with chemotherapy regimens or immune checkpoint inhibitors (ICIs) in the treatment of cancer patients. We surmise that manipulation of microbes may guide personalized therapeutic interventions to facilitate anticancer immune response.© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Citation

Jumin Huang, Fugang Duan, Chun Xie, Jiahui Xu, Yizhong Zhang, Yuwei Wang, Yu-Ping Tang, Elaine Lai-Han Leung. Microbes mediated immunogenic cell death in cancer immunotherapy. Immunological reviews. 2023 Aug 08

PMID: 37553793

search → result