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Role of helicity in the nonenzymatic template-directed primer extension of DNA.
Sung Joon Park, Kimberley Laura Callaghan, Amanda Vera Ellis
Organic & biomolecular chemistry 2023 Aug 23Sizes of these terms reflect their relevance to your search.
Complexing a DNA primer with an RNA template showed improved nonenzymatic template-directed primer extension, attributed to a shift in the DNA helicity from a B-type towards an A-type helix. A 2-fold (deoxyadenosine) and 4.5-fold (deoxycytidine) increase in conversion from initial DNA primer to a primer + 1 nucleotide product was observed.
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Sung Joon Park, Kimberley Laura Callaghan, Amanda Vera Ellis. Role of helicity in the nonenzymatic template-directed primer extension of DNA. Organic & biomolecular chemistry. 2023 Aug 23;21(33):6702-6706
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PMID: 37555399
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