Application of PCT, IL-6, CRP, and WBC for Diagnosing Neonatal Sepsis.

XiaoHong An, XiaoHong Zhang, Yi ShangGuan

Clinical laboratory 2023 Aug 01

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The purpose of this study was to investigate the diagnostic value of combined detection of PCT, IL-6, CRP, and WBC in neonatal sepsis. The study selected 50 neonatal sepsis patients treated in Pucheng County Hospital from April 2018 to June 2020 as the patient group, and 50 healthy newborns as the control group. Before treatment, white blood cell count (WBC) was performed on all neonates, and serum PCT, IL-6, and CRP levels were detected by ELISA. After treatment, serum levels of these four biomarkers in the effective/non-effective groups were observed. The results noted higher levels of these four biomarkers in the patient group rather than the control group before treatment, and in the effective group rather than the non-effective group after treatment. ROC analysis found that the area under curve (AUC), specificity and sensitivity of the combined detection were better than those of the single detection. In short, combined detection of these four biomarkers has a high diagnostic value for neonatal sepsis.

Citation

XiaoHong An, XiaoHong Zhang, Yi ShangGuan. Application of PCT, IL-6, CRP, and WBC for Diagnosing Neonatal Sepsis. Clinical laboratory. 2023 Aug 01;69(8)