Monocyte distribution width (MDW) in sepsis.

Luisa Agnello, Anna Maria Ciaccio, Matteo Vidali, Andrea Cortegiani, Giuseppe Biundo, Caterina Maria Gambino, Concetta Scazzone, Bruna Lo Sasso, Marcello Ciaccio

Clinica chimica acta; international journal of clinical chemistry 2023 Aug 01

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Sepsis is a life-threatening syndrome due to a dysregulated host response to infection, which can be caused by bacterial, viral, or fungal infection. Thus, it is crucial to know how the different microorganisms influence the levels of a biomarker. In the last decade, monocyte distribution width (MDW) has emerged as a promising sepsis biomarker, especially in acute settings, such as the Emergency Department and Intensive Care Unit. In this article, we explore the relationship between MDW and the different pathogens causing infection. Noteworthy, MDW is not a biological molecule, but it is calculated by a mathematical formula based on monocyte characteristics. Monocytes represent the first line defence against microorganisms and undergo activation upon infection, independently from the invading pathogen. According to the knowledge on the biomarker biology and the few literatures evidence, MDW may be considered a biomarker of sepsis, independent of the causative pathogen. However, further investigations are warranted before drawing definite conclusion. Copyright © 2023. Published by Elsevier B.V.

Citation

Luisa Agnello, Anna Maria Ciaccio, Matteo Vidali, Andrea Cortegiani, Giuseppe Biundo, Caterina Maria Gambino, Concetta Scazzone, Bruna Lo Sasso, Marcello Ciaccio. Monocyte distribution width (MDW) in sepsis. Clinica chimica acta; international journal of clinical chemistry. 2023 Aug 01;548:117511