Langerhans Cell Histiocytosis Showed Intense Uptake of 68 Ga-FAPI.

Qingqing Pan, Hongzhe Zhang, Xinxin Cao, Jian Li, Yaping Luo

Clinical nuclear medicine 2023 Oct 01

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A 23-year-old man was recently diagnosed with Langerhans cell histiocytosis (LCH). 68 Ga-FAPI PET/CT showed multiple lesions with intense FAPI uptake in the axial and appendicular skeleton with lytic or mixed bone destruction, consistent with osseous lesions of LCH. FAPI-avid foci around the right atrium and inferior vena cava, as well as micronodules and thin-walled cysts in the lungs, were also noted, possibly also involvement of LCH. This case suggested that 68 Ga-FAPI PET/CT may have the potential to be applied in evaluation of LCH. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

Citation

Qingqing Pan, Hongzhe Zhang, Xinxin Cao, Jian Li, Yaping Luo. Langerhans Cell Histiocytosis Showed Intense Uptake of 68 Ga-FAPI. Clinical nuclear medicine. 2023 Oct 01;48(10):894-895