Soluble HLA-G (sHLA-G) measurement might be useful as an early diagnostic biomarker and screening test for gastric cancer.

Scientific reports 2023 Aug 12

filter terms:

Gastric cancer (GC) is the fifth most frequent malignancy worldwide and has a high mortality rate related to late diagnosis. Although the gold standard for the GC diagnosis is endoscopy with biopsy, nonetheless, it is not cost-effective and is invasive for the patient. The Human leukocyte antigen G (HLA-G) molecule is a checkpoint of the immune response. Its overexpression in cancer is associated with immune evasion, metastasis, poor prognosis, and lower overall survival. We evaluate the plasma levels of soluble HLA-G, (sHLA-G) in patients with GC and benign gastric pathologies using an ELISA test. A higher concentration of sHLA-G in patients with GC than in those with benign pathologies, higher levels of plasma sHLA-G in women with GC compared with men and significant differences in the sHLA-G levels between the benign gastric pathologies evaluated, was our main findings. As no significant differences were found between the GC assessed stages in our study population, we suggest that sHLA-G is not an adequate marker for staging GC, but it does have diagnostic potential. In addition to providing information on the potential of sHLA-G as a diagnostic marker for GC, our study demonstrate that HLA-G molecules can be found in the membrane of exosomes, which highlights the need to perform studies with a larger number of samples to explore the functional implications of HLA-G positive exosomes in the context of gastric cancer, and to determine the clinical significance and possible applications of these findings in the development of non-invasive diagnostic methods. © 2023. Springer Nature Limited.

Citation

Lidy Vannessa Mejía-Guarnizo, Paula Stefanny Monroy-Camacho, Daniel Esteban Rincón-Rodríguez, Andrés Rincón-Riveros, Daniel Augusto Martinez-Vargas, Carlos Alexander Huertas-Caro, Ricardo Oliveros-Wilches, Ricardo Sanchez-Pedraza, Marcela Nuñez-Lemus, Carlos Felipe Cristancho-Lievano, Adriana Milena Castellanos-Moreno, Lina María Martinez-Correa, Josefa Antonia Rodríguez-García. Soluble HLA-G (sHLA-G) measurement might be useful as an early diagnostic biomarker and screening test for gastric cancer. Scientific reports. 2023 Aug 12;13(1):13119